Reconstituted surfactants having improved properties

摘要

Reconstituted surfactants comprising a lipid carrier, a polypeptide analog of the native surfactant protein SP-C, and a polypeptide analog of the native surfactant protein SP-B are useful for the treatment and/or prophylaxis of RDS and other respiratory disorders.

主权项

1. A reconstituted surfactant, comprising:
(a) a lipid carrier; (b) at least one polypeptide represented by formula (Ic) (SEQ ID NO: 15):
IPSSPVHLKRLKLLLLLLLLILLLILGALLΩpGpLp  (Ic) wherein: Ω is an amino acid residue selected from the group consisting of M, M which is oxidized at the sulfur atom, I, L, and nL; and each p is independently 0 or 1, or at least one pharmaceutically acceptable salt thereof, or at least one blocked N- and/or C-terminus derivative thereof; and (c) at least one polypeptide represented by formula (II) (SEQ ID NO: 11):
CfΔLCRALIKRIQAΩIPKGGRΩLPQLVCRLVLΦCSf  (II) wherein: Δ is W; each Ω is independently an amino acid residue selected from the group consisting of M, I, L, and nL; Φ is R; and f is 1, or at least one pharmaceutically acceptable salt thereof, or at least one blocked N- and/or C-terminus derivative thereof, wherein said polypeptide represented by formula (II) is in the form of disulfide linked molecule with intramolecular disulfide linkages between the two Cys residues in position 1 and 33 and between the two Cys residues in position 4 and 27, and wherein said lipid carrier comprises a mixture of phospholipids.