Processes for the preparation of an apoptosis-inducing agent

摘要

Provided herein is a process for the preparation of an apoptosis-inducing agent, and chemical intermediates thereof. Also provided herein are novel chemical intermediates related to the process provided herein.

主权项

1. A process for the preparation of Compound 2 of the formula:which comprises:
(a) combining a compound of formula (K): wherein R is C1 to C12 alkyl, with a tert-butoxide salt, an aprotic organic solvent, and water to provide a compound of formula (L): (b′) combining the compound of formula (L) with a compound of formula (P):  and 1 -ethyl-3 -(3 -dimethylaminopropyl)carbodiimide hydrochloride (EDAC), 4-dimethylaminopyridine (DMAP), and an organic solvent to provide the compound of formula (2).