摘要 |
<p>Peptides of the formula X-phe-ile-gly-leu-met-NH2 where X is H or the acyl residue of an a -amino acid excepting L-lysine and L-alanine, or the acyl residue of a dipeptide with the exception of H-asp(OH)-ala-, its protected derivatives having the amino groups and the carboxyl groups not involved in the formation of peptide links blocked by protecting groups capable of being removed by acidolysis or hydrogenolysis and their non-toxic, pharmaceutically acceptable acid addition salts are prepared by reacting an a -amino-acid or a polypeptide with another polypeptide whose amino acid sequences are part of the above sequence, the amino and carboxylic acid groups not involved in the condensation being suitably protected and, if desired, removed from the final product. Intermediates prepared include: BOC-phe-ile-gly OEt and the free acid; BOC - pro - ONP; BOC - met - ONP and BOC - asp (NH2) - BOC - lys OMe (where BOC = t-butyloxy carbonyl and NP = p-nitrophenyl). Pharmaceutical compositions comprise the compounds of the invention together with a pharmaceutically acceptable carrier. The compositions, which are hypotensive agents, may be in a form suitable for parenteral administration.</p> |