USE OF TRANSFECTED OR TRANSDUCED MAMMALIAN CELLS FOR TREATING BONE PATHOLOGIES

摘要

The present invention relates to the use of a vector selected from the group consisting of adenoviruses, adeno-associated viruses, retroviruses and plasmids as agents for ex vivo transfection or transduction of mammalian osteoblasts to produce therapeutic proteins acting as medicaments for the treatment of a bone pathology selected from the group consisting of local or systemic bone mass loss, bone substance loss or bone structure disorders, bone fractures with bone substance loss, defect fractures, pseudoarthrosis, Sudek's disease, bone defect conditions after operations, bone substance loss in endoprothesis loosening, periarticular osteolysis, rheumatic diseases and osteonecrosis and local or systemic osteolytic conditions, wherein the vector comprises a cDNA encoding a therapeutic protein selected from the group consisting of BMP, hIL-1 Ra and TGF-beta. In one embodiment, herpes simplex virus may be used as the vector.