Method for treating ocular neovascularization

摘要

Methods are provided for the treatment of ocular neovascularization by increasing, in an individual afflicted with ocular neovascularization, in vivo concentrations of an endostatin protein in the ocular tissues of the individual to an ocular neovascularization inhibiting effective amount, where the endostatin protein has anti-ocular neovascularization activity in vivo.

主权项

1. A method for ameliorating or reducing the rate of ocular neovascularization in an individual afflicted with ocular neovascularization, comprising:
directly administering to the eye or eyes of the individual a replication-defective viral vector that operably encodes and expresses a functionally active endostatin wherein the administering ameliorates or reduces the rate of ocular neovascularization, wherein the viral vector is administered to the eye or eyes of the individual intraocularly or subretinally.