| 发明名称 | Inhibitors of IAP | ||
| 摘要 | Novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies and have the general formula I:; wherein R1, R2, R3, R4, R5 and R6 are as described herein. | ||
| 申请公布号 | US9238675(B2) | 申请公布日期 | 2016.01.19 |
| 申请号 | US201414269739 | 申请日期 | 2014.05.05 |
| 申请人 | GENENTECH, INC. | 发明人 | Cohen Frederick;Gazzard Lewis J.;Tsui Vickie Hsiao-Wei;Flygare John A. |
| 分类号 | A61K38/48;A61K38/55;C07K14/81;C07K5/08;C07K5/09;C07K5/083;A61K38/00 | 主分类号 | A61K38/48 |
| 代理机构 | Millen White Zelano and Branigan, PC | 代理人 | Millen White Zelano and Branigan, PC ;Sopp John;Zelano Anthony |
| 主权项 | 1. A method for inhibiting the binding of an IAP protein to a caspase protein comprising contacting said IAP protein with a compound according to formula Iwherein Ph is phenyl; R1 is C3-7 cycloalkyl; and R2 R3, R4, R5, and R6 are each independently in each occurrence H or C11-6 alkyl;or a pharmaceutically acceptable salt thereof. | ||
| 地址 | South San Francisco CA US | ||