Antimalarial agents that are inhibitors of dihydroorotate dehydrogenase

摘要

Inhibitors of parasitic dihydroorotate dehydrogenase enzyme (DHOD) are candidate therapeutics for treating malaria. Illustrative of such therapeutic agents include the compound:;
and a triazolopyrimidine class of compounds that conform to Formula IX:
;
and their solvates, stereoisomers, tautomers and pharmaceutically acceptable salts.

主权项

1. A compound selected from:and stereoisomers, tautomers, solvates, prodrugs and pharmaceutically acceptable salts thereof.