| 发明名称 |
P2X3 receptor antagonists for treatment of pain |
| 摘要 |
The subject invention relates to novel P2X3 receptor antagonists that play a critical role in treating disease states associated with pain, in particular peripheral pain, inflammatory pain, or tissue injury pain that can be treated using a P2X3 receptor subunit modulator. |
| 申请公布号 |
US9238647(B2) |
申请公布日期 |
2016.01.19 |
| 申请号 |
US201013259040 |
申请日期 |
2010.03.15 |
| 申请人 |
Merck Sharp & Dohme Corp. |
发明人 |
Burgey Christopher S.;Deng Zhengwu J.;Nguyen Diem;Paone Daniel V.;Potteiger Craig M.;Stauffer Shaun R.;Segerdell Carolyn;Nomland Ashley;Lim John J. |
| 分类号 |
C07D471/04;A61K31/195;A61K31/415;A61K33/00;A61K45/06;C07D413/12 |
主分类号 |
C07D471/04 |
| 代理机构 |
|
代理人 |
Ayler Sylvia A.;Todaro John C. |
| 主权项 |
1. A compound represented in Tables 9 and 10:TABLE 9ExampleR3aB9.19.29.39.49.59.69.79.89.99.109.119.129.139.149.159.169.179.189.199.209.219.229.239.249.259.269.279.289.299.309.319.329.339.349.359.369.379.389.399.409.419.429.439.449.459.469.479.489.499.509.519.529.539.549.559.569.579.589.599.609.619.629.63ExampleR6R6a9.1H9.2H9.3H9.4H9.59.6H9.7H9.89.99.109.11H9.12H9.139.14H9.15H9.16H9.179.189.19H9.20H9.21H9.229.239.249.259.269.27H9.289.299.309.319.32H9.339.349.359.36H9.37H9.389.399.40H9.419.429.439.449.459.469.479.48H9.49H9.509.519.529.539.549.559.569.579.589.599.609.619.629.63TABLE 10ExampleR3aB10.110.2ExampleR6aR610.110.2or pharmaceutically acceptable salts and individual enantiomers thereof. |
| 地址 |
Rahway NJ US |
