Method, device and system for modulating an activity of brown adipose tissue in a vertebrate subject

摘要

Devices, systems, and methods are disclosed herein for treatment of a disease, disorder, or condition in a vertebrate subject. A device is provided that includes one or more passive cooling elements configured to be applied to one or more tissues of a vertebrate subject to modulate at least one activity of brown adipose tissue of the vertebrate subject, wherein at least a portion of the one or more passive cooling elements is configured to be implantable, and wherein the one or more passive cooling elements includes a first portion configured to be in association with the one or more tissues to be cooled, and a second portion configured to be placed in association with one or more tissues adjacent to an external epidermal tissue of the vertebrate subject.

主权项

1. A device comprising:
one or more implantable cooling elements configured to be applied to one or more tissues of a vertebrate subject, wherein each of the one or more implantable cooling elements includes a first portion configured to be in association with one or more first tissues to be cooled, and a second portion including two or more branches configured to be placed in association with one or more second tissues adjacent to an external epidermal tissue of the vertebrate subject; and at least one programmable controller operably configured to provide instructions to the one or more implantable cooling elements in response to information regarding a plasma level of one or more of a metabolic analyte, a sugar, a lipoprotein, or a fatty acid in the vertebrate subject.