| 发明名称 | Cyclic peptide and conjugate thereof for binding to keratinocytes | ||
| 摘要 | A cyclic peptide capable of binding specifically to the α2 I domain of a collagen binding integrin receptor may be conjugated to a drug containing particle via a linker moiety. The conjugate may be used to target a therapeutic drug to a cell expressing a collagen binding integrin receptor on its surface. | ||
| 申请公布号 | US9238056(B2) | 申请公布日期 | 2016.01.19 |
| 申请号 | US201214000811 | 申请日期 | 2012.02.21 |
| 申请人 | LEO PHARMA A/S | 发明人 | Knudsen Nina Østergaard;Thormann Thorsten |
| 分类号 | A61K38/04;A61K31/593;A61K8/64;A61K38/12;A61K47/48;C07K7/06;C07K7/64;A61K9/127;A61K31/047;A61K38/00 | 主分类号 | A61K38/04 |
| 代理机构 | Birch Stewart Kolasch & Birch, LLP | 代理人 | Birch Stewart Kolasch & Birch, LLP |
| 主权项 | 1. A pharmaceutical composition for topical application comprising a conjugate of a drug-containing carrier particle and a cyclic peptide capable of binding specifically to the α2 I domain of the integrin α2β1 receptor of the subgroup of collagen binding integrin receptors, said peptide having the amino acid sequence(SEQ ID NO: 2)Ser-Thr-Arg-Lys-Lys-His-Asp-Asn-Ala-Gln-Ser-Lys-L wherein L is a linker moiety comprising a thiol group that is suitable for conjugating the drug-containing carrier particle; and a pharmaceutically acceptable carrier or excipient. | ||
| 地址 | Ballerup DK | ||