Alkali-free bioactive glass composition

摘要

The present invention relates to development of bioactive glass/glass-ceramic composition that are able to promote a fast deposition layer of carbonated hydroxyapatite upon immersion in simulated body fluid (SBF) for time periods as short as one hour. Such composition might include fluorides, and a variety of oxides (or their precursor compounds), such as Na2O—Ag2O—SrO—CaO—MgO—ZnO—P2O5—SiO2—Bi2O3—B2O3—CaF2, be prepared by the melt route or by the sol-gel process, with the specific composition and the preparation route selected according to the intended functionalities, which can present controlled biodegradation rate and bactericidal activity. The powders derived from glass melts purred in cold water (frits) may completely densify by sintering at temperatures up to 800° C. without devitrification, resulting in bioglass compacts with high flexural strength (˜85 MPa). The bioactive glass powders prepared by sol-gel densify at lower temperatures due to their higher specific surface area and reactivity.

主权项

1. A bioactive glass composition comprising the following components:
(a) calcium oxide (CaO), between 20-60%; (b) magnesium oxide (MgO), between 14-25%; (c) phosphorous pentoxide (P2O5), between 0-10%; (d) silica (SiO2) between 29-60%; and (e) calcium fluoride in the form of CaF2, between 0-5%; wherein all the percentages are molar percentages, and wherein the composition is alkali-free.