发明名称 |
Pharmaceutical composition containing KW-6002 and fluoxetine or paroxentine |
摘要 |
The present invention provides pharmaceutical compositions, which are useful for treatment of depression and the like, and which comprises a compound having an adenosine A2A receptor antagonistic activity such as (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione or a pharmaceutically acceptable salt thereof and an antidepressant drug (for example, a tricyclic antidepressant, a tetracyclic antidepressant, a selective serotonin reuptake inhibitor, a selective noradrenalin reuptake inhibitor, a dopamine reuptake inhibitor, a serotonin-noradrenalin reuptake inhibitor, monoamine oxidase inhibitor, a 5-HT2 antagonist or the like), and the like. |
申请公布号 |
US9238033(B2) |
申请公布日期 |
2016.01.19 |
申请号 |
US201313869076 |
申请日期 |
2013.04.24 |
申请人 |
KYOWA HAKKO KIRIN CO., LTD. |
发明人 |
Kase Hiroshi;Kobayashi Minoru;Shiozaki Shizuo;Mori Akihisa;Seno Naoki |
分类号 |
A61K31/522;A61K31/138;A61K31/137;A61K31/335;A61K31/343;A61K31/36;A61K31/38;A61K31/381;A61K31/435;A61K31/496;A61K31/52;A61K31/5375;A61K31/55;A61K31/553;A61K31/16;A61K31/4525;A61K45/06 |
主分类号 |
A61K31/522 |
代理机构 |
Fitzpatrick, Cella, Harper & Scinto |
代理人 |
Fitzpatrick, Cella, Harper & Scinto |
主权项 |
1. A method for treating depression, which comprises administering
(a) (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione represented by formula (I): or a pharmaceutically acceptable salt thereof; and (b) an antidepressant drug selected from the group consisting of fluoxetine and paroxetine, or pharmaceutically acceptable salts thereof, simultaneously or separately at a time interval. |
地址 |
Tokyo JP |