| 发明名称 | Retinol-modified collagen, method for producing same, and external composition for skin containing same | ||
| 摘要 | Disclosed is a compound which exhibits a higher effect of preventing wrinkle formation, a higher effect of improving wrinkles, a higher effect of making the skin beautiful, and a higher effect of improving skin quality than conventional retinol and retinol derivatives in a sustained manner. Further disclosed are a method for producing the same, and an external composition for the skin and a sheet-shaped cosmetic each containing the same as an active ingredient. More specifically disclosed are retinol-modified collagen in which a dicarboxylic acid is attached to at least one hydroxyl group of collagen and retinol is attached to a carboxyl group of at least one attached dicarboxylic acid, a method for producing the same, and an external composition for the skin and a sheet-shaped cosmetic each containing the same as an active ingredient. | ||
| 申请公布号 | US9238688(B2) | 申请公布日期 | 2016.01.19 |
| 申请号 | US201113703477 | 申请日期 | 2011.06.15 |
| 申请人 | NATIONAL UNIVERSITY CORPORATION NARA INSTITUTE OF SCIENCE AND TECHNOLOGY;SUNSTAR INC. | 发明人 | Tanihara Masao;Takaichi Kana;Maeda Mariko;Mitsui Tsukasa;Yamamoto Kazushi;Hirano Akiko |
| 分类号 | C07K14/78;A61Q19/08;A61Q19/00;C07K1/107;A61K8/67;A61K31/07;A61K38/39;A61Q1/00;A61Q1/02;A61Q1/12;A61Q5/02;A61Q5/12;A61Q19/10 | 主分类号 | C07K14/78 |
| 代理机构 | Wenderoth, Lind & Ponack, L.L.P. | 代理人 | Wenderoth, Lind & Ponack, L.L.P. |
| 主权项 | 1. A retinol-modified collagen, comprising a peptide unit represented by formula (2): | ||
| 地址 | Nara JP | ||