Anti-inflammatory metabolite derived from omega-3-type fatty acid

摘要

The purpose is to provide a compound which can overcomes the disadvantages of conventional steroid drugs and NSAID. It is found that specific epoxy monohydroxy forms of eicosapentaenoic acid, docosahexaenoic acid and docosapentaenoic acid which are independently represented by formulae [chemical formula 1], [chemical formula 5] and the like have an inhibitory activity on neutrophils. This compound can inhibit the invasion of neutrophils into tissues and the activation of neutrophils which are observed in acute inflammations.

主权项

1. A compound selected from the group consisting of:hydrates of the compound, pharmaceutically acceptable salts of the compound, and hydrates of the salts; wherein,
whenis a single bond,
P1 is hydrogen, alkyl, or hydroxy and R1 is hydrogen, or substituted or unsubstituted, branched or unbranched alkyl; whenis a double bond, P1 and R1 are not present;
X is —C(O)OR2; R2 is a hydrogen, substituted or unsubstituted alkyl, or substituted or unsubstituted aryl; and double bonds of the compound may each be independently in either a cis or trans configuration.