3-cyanoanilinoalkylarylpiperazine derivative and use thereof in preparing drugs

摘要

Disclosed in the present invention is a 3-cyanoanilinoalkylarylpiperazine derivatives and use thereof in preparing drugs; the 3-cyanoanilinoalkylarylpiperazine derivatives disclosed by the present invention has very useful pharmaceutical properties and good tolerance, especially the use as novel analgesic drugs, novel antidepressants, and novel analgesic and antidepressive drugs. This class of compounds are central analgesics regulating 5-hydroxytrptamine, and also are novel antidepressants regulating 5-hydroxytrptamine. This class of compounds also has less toxic and side effects and a higher safety range. The 3-cyanoanilinoalkylarylpiperazine derivative is a compound shown as formula (III) or free base or salt thereof:;

主权项

1. A 3-cyanoanilinoalkylarylpiperazine derivative having a structure according to formula (III), or salt thereof:wherein:
R is C1-C5 linear or branched alkyl, wherein the hydrogen atom(s) of the alkyl may be optionally replaced by 1-3 fluorine atoms; R1 is H, OCH3, Cl or CH3; R2 is H, CF3, Cl or CH3; X and Y are independently CH or N; and n=0, 1 or 2.