Analyte sensors and methods for making and using them

摘要

Embodiments of the invention provide analyte sensors having elements designed to modulate their chemical reactions as well as methods for making and using such sensors. In certain embodiments of the invention, the sensor includes a hydrophilic comb-copolymer having a central chain and a plurality of side chains coupled to the central chain, wherein at least one side chain comprises a silicone moiety.

主权项

1. An analyte sensor apparatus for implantation within a mammal, the analyte sensor apparatus comprising:
a base layer; a conductive layer disposed upon the base layer wherein the conductive layer includes a working electrode; an analyte sensing layer disposed on the conductive layer, wherein the analyte sensing layer detectably alters the electrical current at the working electrode in the conductive layer in the presence of an analyte; and an analyte modulating layer disposed on the analyte sensing layer, wherein: the analyte modulating layer modulates the diffusion of the analyte therethrough; the analyte modulating layer comprising a hydrophilic comb-copolymer having a central chain and a plurality of side chains coupled to the central chain; the hydrophilic comb-copolymer comprises a polydimethyl siloxane monomethacrylate, methyl methacrylate; and methoxy poly(ethylene oxide)monomethacrylate comb-copolymer; the analyte modulating layer exhibits a glucose diffusion coefficient of between 2.3×10−9 cm2/s and 140×10−9 cm2/s; and the analyte modulating layer comprises: 30-50 wt % polydimethyl siloxane monomethacrylate; 30-55 wt % methyl methacrylate; and 15-25 wt % methoxy poly(ethylene oxide)monomethacrylate, such that the comb-copolymer exhibits a molecular weight from 139 kg/mol to 196 kg/mol.