发明名称 2-AMINOOXAZOLINES AS TAAR1 LIGANDS
摘要 <p>The invention relates to compounds of formula (I) wherein R1 is aryl or heteroaryl, wherein the aryl and heteroaryl groups may be unsubstituted or substituted by one to three substituents, selected from the group consisting of cycloalkyl, phenyl, phenyloxy, benzyl, benzyloxy, halogen, lower alkyl, lower alkoxy, heteroaryl, piperidin-1-yl or by lower alkyl substituted by halogen, or is aryl or heteroaryl wherein at least one hydrogen atom is replaced by deuterium or tritium; R2 is hydrogen, lower alkyl or is benzyl unsubstituted or substituted by alkoxy or halogen; or R1 and R2 form together with the N-atom to which they are attached 2,3-dihydroindol-1-yl or 3,4-dihydro-quinolin-1-yl; R3 is hydrogen or lower alkyl or to a pharmaceutically suitable acid addition salt thereof for the treatment of CNS disorders.</p>
申请公布号 CA2676944(C) 申请公布日期 2016.01.19
申请号 CA20082676944 申请日期 2008.02.05
申请人 F. HOFFMANN-LA ROCHE AG 发明人 GALLEY, GUIDO;GROEBKE ZBINDEN, KATRIN;NORCROSS, ROGER;STALDER, HENRI
分类号 C07D263/28;A61K31/421;A61K31/422;A61P25/00;C07D413/06 主分类号 C07D263/28
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