发明名称 |
TETRAHYDROISOQUINOLIN-1-ONE DERIVATIVE OR SALT THEREOF |
摘要 |
[Problems] To provide a pharmaceutical, in particular a compound which can be used as a therapeutic agent for irritable bowel syndrome (IBS). [Means for Solving Problems] It was found that a tetrahydroisoquinolin-1-one derivative having an amide group at the 4-position or a pharmaceutically acceptable salt thereof has an excellent bombesin 2 (BB2) receptor antagonistic action. It is also found that the tetrahydroisoquinolin-1-one derivative is highly effective on bowel movement disorders. From the above, the tetrahydroisoquinolin-1-one derivative of the present invention is useful as a therapeutic agent for diseases associated with a BB2 receptor, in particular IBS. |
申请公布号 |
HRP20151336(T1) |
申请公布日期 |
2016.01.15 |
申请号 |
HR2015P001336T |
申请日期 |
2015.12.07 |
申请人 |
SELDAR PHARMA INC. |
发明人 |
HISAMICHI, HIROYUKI;SHIMADA, ITSURO;ISHIHARA, TSUKASA;TAKUWA, TOMOFUMI;SHIMIZU, TAKAFUMI;ISHIKAWA, NORIKO;MAENO, KYOICHI;SEKI, NORIO |
分类号 |
C07D217/26;A61K31/472;A61K31/496;A61K31/497;A61K31/501;A61K31/506;A61K31/53;A61K31/5377;A61K31/695;A61P1/00;A61P35/00;C07D401/04;C07D401/06;C07D401/12;C07D405/04;C07D405/06;C07D405/14;C07D409/12;C07D413/12;C07D417/12 |
主分类号 |
C07D217/26 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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