| 发明名称 |
NOVEL INSULIN ANALOG AND USE THEREOF |
| 摘要 |
The present invention relates to an insulin analog that has a reduced insulin titer and a reduced insulin receptor binding affinity compared to the native form for the purpose of increasing the blood half-life of insulin, a conjugate prepared by linking the insulin analog and a carrier, a long-acting formulation including the conjugate, and a method for preparing the conjugate. |
| 申请公布号 |
US2016008483(A1) |
申请公布日期 |
2016.01.14 |
| 申请号 |
US201414769495 |
申请日期 |
2014.02.26 |
| 申请人 |
HANMI PHARM. CO., LTD |
发明人 |
HWANG Sang Youn;HUH Yong Ho;KIM Jin Young;HONG Sung Hee;CHOI In Young;JUNG Sung Youb;KWON Se Chang;KIM Dae Jin;KIM Hyun Uk;JANG Myung Hyun;KIM Seung Su |
| 分类号 |
A61K47/48;C07K14/62 |
主分类号 |
A61K47/48 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An insulin analog having a reduced insulin titer compared to the native form, wherein an amino acid in B chain or A chain of insulin is modified. |
| 地址 |
Hwaseong-si, Gyeonggi-do KR |
