COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR TREATING DISORDERS ASSOCIATED WITH THE 5-HT1A AND 5-HT2A RECEPTORS

摘要

Alkyl-piperazine-phenyl 4 (3H)-quinazolinones compounds of general formula (I) below are provided that are pharmacologically active and able to act on the 5-HT1A and 5-HT2A serotonin receptors in a manner that promotes the control, relief or cure of disorders associated with these receptors, and pharmaceutical compositions containing the compounds for the treatment of disorders associated with these receptors. These compounds and their pharmaceutical compositions are useful in the treatment of conditions such as depression, anxiety, phobias, addictions, aggressiveness, impulsiveness, panic, psychotic, eating and sleep disorders, obsessive-compulsive disorder and female sexual dysfunctions, including loss of sexual desire, inhibition of sexual desire and absence of sexual desire, among other disorders associated with these receptors.;

主权项

1. A method of treating female sexual disorders associated with the 5-HT1A and 5-HT2A serotonin receptors selected from the group consisting of loss of sexual desire, inhibition of sexual desire and absence of sexual desire, comprising administering to a patient in need thereof a therapeutically effective quantity of a compound of general formula (I): wherein, n=2, R1 is hydrogen or ethyl, and R2 is selected from the group consisting of: 3-trifluormethylphenyl, 2-chlorophenyl, 2-methylphenyl, 2,3-dimethylphenyl, 2-cyanophenyl, 2-methoxyphenyl and 2-ethoxyphenyl, or pharmaceutically acceptable salts thereof.