| 摘要 |
PROBLEM TO BE SOLVED: To provide ligand drug conjugates and linker-drug conjugates for targeted delivery of drugs.SOLUTION: Ligand drug conjugates include a ligand, such as an antibody, for targeting the conjugate to a target cell or target tissue. The conjugates further include a &bgr;-glucuronide-based linker comprising a site that can be cleaved by an enzyme having &bgr;-glucuronidase activity. The linker is attached to the ligand and to a drug. The invention further provides methods of treating cancer, immune disease, infectious disease and other diseases or disorders using a ligand drug conjugate including the &bgr;-glucuronide-based linker. |
