发明名称 |
EFFECTIVE GENERATION OF TUMOR-TARGETED T CELLS DERIVED FROM PLURIPOTENT STEM CELLS |
摘要 |
The present invention relates to the field of adoptive immunotherapy. The invention provides methods for generating phenotypically defined, functional, and/or expandable T cells from pluripotent stem cells engineered through safe genetic modifications. The engineered cells may provide one or more of: 1) targeting a specific predetermined antigen expressed on the cell surface of a target cell in an HLA independent manner, 2) enhanced survival and functional potential 3) “off-the-shelf” T cells for administration to multiple recipients, eventually across immunogenic barriers, and/or 4) cytotoxic potential and anti-tumor activity. |
申请公布号 |
US2016009813(A1) |
申请公布日期 |
2016.01.14 |
申请号 |
US201514873836 |
申请日期 |
2015.10.02 |
申请人 |
MEMORIAL SLOAN-KETTERING CANCER CENTER |
发明人 |
Themeli Maria;Sadelain Michel;Kloss Christopher C. |
分类号 |
C07K16/30;C07K14/47;C07K14/705;C12N5/0783;A61K35/17;C07K14/725 |
主分类号 |
C07K16/30 |
代理机构 |
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代理人 |
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主权项 |
1. A T cell that is generated from a pluripotent stem cell that expresses a chimeric antigen receptor (CAR). |
地址 |
New York NY US |