BENZO FIVE-MEMBERED NITROGEN HETEROCYCLIC PIPERIDINE OR PIPERAZINE DERIVATIVES AND PREPARATION METHODS AND PHARMACEUTICAL COMPOSITIONS THEREOF

摘要

The present invention relates to the compounds of formula (I) or pharmaceutically acceptable salts thereof: wherein R1, R2, X, Y, A and B are defined in the description. Also disclosed in the present invention are the methods for preparing the compounds of formula (I) or pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising the compounds of formula (I) or pharmaceutically acceptable salts thereof.;

主权项

1. A compound of the following formula (I) or pharmaceutically acceptable salt thereof: wherein, R1 represents an aromatic group or an aliphatic cyclic group, each of which is mono- or polysubstituted with R3, R3 is H, halogen, CN, C1-C6 alkyl, C1-C6 alkoxy, CHO, CO(C1-C6 alkyl, COO(C1-C6 alkyl), COOH, NO2, NH2, NH(C1-C6 alkyl), N(C1-C6alkyl)2, SH, S(C1-C6 alkyl), —S(O)(C1-C6 alkyl), —S(O)2H or —S(O)2(C1-C6 alkyl), each of which alkyl moiety is optionally substituted with one or more halogen atoms; when R3 are groups for polysubstitution, each R3 is independently selected from the group consisting of H, halogen, CN, C1-C6 alkyl, C1-C6 alkoxy, CHO, CO(C1-C6 alkyl), COO(C1-C6 alkyl), COOH, NO2, NH2, NH(C1-C6 alkyl), N(C1-C6alkyl)2, SH, S(C1-C6 alkyl), —S(O)(C1-C6 alkyl), —S(O)2H or —S(O)2(C1-C6 alkyl), each of which alkyl moiety is optionally substituted with one or more halogen atoms; A, B and X each independently represents CH or N; R2 is H, halogen, CN, C1-C6 alkyl, C1-C6 alkoxy, CHO, CO(C1-C6alkyl), COO(C1-C6 alkyl), COOH, NO2, NH2, NH(C1-C6 alkyl), N(C1-C6alkyl)2, SH, S(C1-C6 alkyl), —S(O)(C1-C6 alkyl), —S(O)2H or —S(O)2(C1-C6 alkyl), each of which alkyl moiety is optionally substituted with one or more halogen atoms; when R2 are groups for polysubstitution, each R2 is independently selected from the group consisting of H, halogen, CN, C1-C6 alkyl, C1-C6 alkoxy, CHO, CO(C1-C6 alkyl), COO(C1-C6 alkyl), COOH, NO2, NH2, NH(C1-C6 alkyl), N(C1-C6alkyl)2, SH, S(C1-C6 alkyl), —S(O)(C1-C6 alkyl), —S(O)2H or —S(O)2(C1-C6 alkyl), each of which alkyl moiety is optionally substituted with one or more halogen atoms; and Y represents a saturated or unsaturated, straight or branched, C1-8 hydrocarbyl chain optionally substituted with one or more halogen atoms, wherein one or more carbon atoms are optionally replaced with heteroatom(s) selected from oxygen, sulfur and nitrogen.