发明名称 |
CO-CRYSTALS OF TRAMADOL AND NSAIDS. |
摘要 |
The present invention relates to co-crystals of tramadol and co-crystal formers selected from NSAIDs, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain. In a preferred embodiment, the co-crystal is a co-crystal of (-) -tramadol and (S) -naproxen (1:2); (+) -tramadol and (R) -naproxen (1:2) or (rac) -tramadol-Hcl-celecoxib (1:1). |
申请公布号 |
MX336318(B) |
申请公布日期 |
2016.01.14 |
申请号 |
MX20110003612 |
申请日期 |
2009.10.16 |
申请人 |
LABORATORIOS DEL DR. ESTEVE, S.A.* |
发明人 |
HELMUT HEINRICH BUSCHMANN;JORDI BENET BUCHHOLZ;JORDI CARLES CERÓN BERTRAN;LLUIS SOLA CARANDELL;CARLOS RAMON PLATA SALAMAN;NICOLAS TESSON |
分类号 |
A61K31/135;A61K31/192;A61P25/04;A61P29/00;C07C59/64;C07C217/74 |
主分类号 |
A61K31/135 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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