SUBSTITUTED-QUINOXALINE-TYPE BRIDGED-PIPERIDINE COMPOUNDS AND THE USES THEREOF

摘要

Compounds of Formula (I):;;where R1, R2, R5, a, and b are disclosed herein, and pharmaceutically acceptable derivatives thereof (a “Substituted-Quinoxaline-Type Bridged-Piperidine Compound”), compositions comprising an effective amount of a Substituted-Quinoxaline-Type Bridged-Piperidine Compound, and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of a Substituted-Quinoxaline-Type Bridged-Piperidine Compound.

主权项

1. A method for treating pain in an animal, comprising administering to an animal in need thereof an effective amount of a compound of Formula (I′): or a pharmaceutically acceptable salt, stereoisomer, or tautomer thereof, wherein:
each R2 is independently selected from -halo;a is 0, 1 or 2;b is 0 or 1;each R5 is independently —H, —OH, —(C1-C3)alkyl, —C(halo)3, or -halo;R1 is —(C9-C14)cycloalkyl or —(C9-C14)bicycloalkyl, each of which is substituted with 1, 2 or 3 independently selected R3 groups;each R3 is independently —(C1-C4)alkyl, —(C2-C6)alkenyl, —(C2-C6)alkynyl, or —(C3-C6)cycloalkyl; andeach halo is independently —F, —Cl, —Br, or —I.