Commands and method of treating cancer via RHO pathway

摘要

Lanosterol derivatives useful as anti-cancer agent, which can inhibit the growth of lung cancer cells, liver cancer cells, mammary cancer cells, brain cancer cells and pancreatic cancer cells, possibly by acting on the RHO pathway. These lanosterol derivatives are represented by compound LD030:;

主权项

1. A compound comprising a property of inhibiting cancer cell growth and is of a formula selected from the group consisting of formula (I), (II), (III), (IV): wherein X, X′ is O, S or NR; R1 and R2 are independently hydrogen, halogen, —OH, —SH, ═O, C1-C5 alkyl group, C1-C5 alkoxy group, p-methyl phenylsulfonyl, alkane-substituted siloxy or C1-C5 alkylamino; R3, R4, and R5 are independently hydrogen, halogen, —OH, —SH, C1-C5 alkyl group, C1-C5 alkoxy group, methylphenylsulfonyl group, a silyl group, or C1-C5 alkyl amino; R is alkyl or hydrogen.