发明名称 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS
摘要 Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described.
申请公布号 US2016009663(A1) 申请公布日期 2016.01.14
申请号 US201314442084 申请日期 2013.11.12
申请人 NEUPHARMA, INC. 发明人 Qian Xiangping;Zhu Yong-liang
分类号 C07D241/44;A61K45/06;C07D401/04;A61K31/498;C07D403/12;C07D413/12;A61K31/5377;C07D241/42 主分类号 C07D241/44
代理机构 代理人
主权项 1. A compound of Formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, and R10 are independently hydrogen, cyano, halo, hydroxy, azido, nitro, carboxy, sulfinyl, sulfanyl, sulfonyl, optionally substituted alkoxy, optionally substituted cycloalkyloxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocycloalkyloxy, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted amino, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted aminocarbonyl, optionally substituted aminosulfonyl, optionally substituted carbamimidoyl, or optionally substituted alkynyl; R9 is hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl; and R11 is hydroxyl, formyl, optionally substituted alkoxy, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, —COR12, —CO2R12, —CONR12R13, —C(NR14)NR12R13, —C(NCN)NR12R13, or —SO2NR12R13, where R12 is optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl; and R13 and R14 are independently hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl; or R12 and R13 may be joined together with any intervening atoms to form an optionally substituted heterocycloalkyl ring; or R9 and R11 may be joined together with any intervening atoms to form an optionally substituted heterocycloalkyl ring.
地址 Foster City CA US