主权项 |
1. A compound according to Formula (I)or a salt thereof, wherein:
one of R2 and R4 is a phenyl monosubstituted with —ORa, —O—C(O)ORa, —O—(CH2)m—C(O)ORa, —C(O)ORa, —O—(CH2)m—NRcRc, —O—C(O)NRcRc, —O—(CH2)m—C(O)NRcRc, —O—C(NH)NRcRc, —O—(CH2)m—C(NH)NRcRc, —NH—(CH2)m—NRcRc or —[NHC(O)]Rd; the other of R2 and R4 is a phenyl monosubstituted or disubstituted with R8; R2 and R4 are different; R5 is fluoro, —CN, or (C1-C3) haloalkyl; each R8 is independently Ra, Rb, or Ra substituted with one Ra or Rb; each Ra is (C1-C6) alkyl, or 3-8 membered cycloheteroalkyl; each Rb is —ORa, —NRcRc, halogen, —CF3, —CN, —NO2, —N3, —SO2NRcRc, —C(O)Ra, —C(O)ORa, —C(O)NRcRc, or —C(NH)NRcRc; each Rc is independently H or Ra; each Rd is independently Ra; and each m is independently an integer from 1 to 2. |