| 摘要 |
A method of generating an induced trophoblast stem cell (iTSC) from a cell is provided. Accordingly there is provided a method comprising expressing within the cell at least one exogenous transcription factor selected from the group consisting of Gata3, Eomes and Tfap2c, under conditions which allow generation of an iTSC from the cell, thereby generating the iTSC from the cell, with the proviso that the method does not consist of expressing within the cell Eomes, Cdx2, Elf5, cMyc and Klf4. Also provided are nucleic acid constructs, isolated cells and iTSCs. |
