发明名称 |
NASOLACRIMAL DRAINAGE SYSTEM IMPLANTS FOR DRUG THERAPY |
摘要 |
An implant for insertion through a punctum and into a canalicular lumen of a patient. The implant includes a matrix of material, a therapeutic agent dispersed in the matrix of material, a sheath disposed over a portion of the matrix of material and configured to inhibit the therapeutic agent from being released from the matrix of material into the canalicular lumen and to allow the therapeutic agent to be released from a surface of the matrix of material to a tear film, and a retention structure configured to retain the implant within the canalicular lumen. |
申请公布号 |
US2016008171(A1) |
申请公布日期 |
2016.01.14 |
申请号 |
US201514858555 |
申请日期 |
2015.09.18 |
申请人 |
Mati Therapeutics Inc |
发明人 |
de Juan, JR. Eugene;Boyd Stephen;Reich Cary;Rapacki Alan;Gifford Hanson S.;Deem Mark |
分类号 |
A61F9/007;A61F9/00;A61K47/34;A61K9/00;A61K31/5575 |
主分类号 |
A61F9/007 |
代理机构 |
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代理人 |
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主权项 |
1. A method for delivery of a therapeutic agent to an eye, comprising:
placing a lacrimal implant through a punctum and into a canalicular lumen of a patient, the implant comprising: a plug body comprising a drug insert; the drug insert comprising:
a matrix of material;a therapeutic agent dispersed in the matrix of material; anda sheath disposed over a portion of the matrix of material and configured to inhibit the therapeutic agent from being released from the matrix of material into the canalicular lumen, wherein when the implant is inserted into the canalicular lumen an exposed surface of the drug insert is in direct contact with tear fluid to allow diffusion of the therapeutic agent from a surface of the matrix of material to a tear film of the eye. |
地址 |
Austin TX US |