发明名称 |
METHOD OF COMPUTATIONAL PROTEIN DESIGN |
摘要 |
A method for constructing a library of amino-acid sequences having a common structural fold, and a method for designing and selecting an amino-acid sequence having a desired affinity to a molecular surface of interest of a molecular entity, using the library, are provided herein. The methods are based on a stochastic sampling of backbone conformations and amino acid conservation patterns observed in experimentally available protein structures having the common structural fold. |
申请公布号 |
WO2016005969(A1) |
申请公布日期 |
2016.01.14 |
申请号 |
WO2015IL50696 |
申请日期 |
2015.07.06 |
申请人 |
YEDA RESEARCH AND DEVELOPMENT CO. LTD. |
发明人 |
FLEISHMAN, SAREL;LAPIDOTH, GIDEON;PSZOLLA, MARIA GABRIELE;NORN, CHRISTOFFER |
分类号 |
G06F19/16;C40B50/02 |
主分类号 |
G06F19/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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