| 摘要 |
PROBLEM TO BE SOLVED: To provide methods for treating various types of cancer/tumor.SOLUTION: The invention relates to an isolated human antibody or an antigen binding fragment thereof which specifically binds to human delta-like ligand 4 (hDll4) for use in treating cancer or reducing or halting tumor growth in a subject by administration in combination with a chemotherapeutic agent. The invention relates to a pharmaceutical composition containing the human antibody or an antigen binding fragment thereof, a chemotherapeutic agent, and a pharmaceutically acceptable carrier. The chemotherapeutic agent is selected from antimitotic agents, platinum-based chemotherapeutic agents, receptor tyrosine kinase inhibitors, pyrimidine analogues, topoisomerase inhibitors, and adjuvants. |
