MICROORGANISM HAVING NOVEL ACRYLIC ACID SYNTHESIS PATHWAY HAVING ENHANCED ACTIVITY OF COA ACYLATING ALDEHYDE DEHYDROGENASE AND METHOD OF PRODUCING ACRYLIC ACID USING THE SAME

摘要

A microorganism capable of producing acrylic acid, comprising a genetic modification that increases activity of CoA acylating aldehyde dehydrogenase (ALDH) catalyzing conversion of 3-hydroxypropionaldehyde (3-HPA) to 3-hydroxy propionyl-CoA (3-HP-CoA) and a genetic modification that increases activity of 3-HP-CoA dehydratase catalyzing conversion of 3-HP-CoA to acrylyl-CoA in the microorganism in comparison with a cell that is not genetically engineered; as well as a method of producing the microorganism, and a method of producing acrylic acid using the same.

主权项

1. A genetically engineered microorganism that produces acrylate, wherein the genetically engineered microorganism comprises
a genetic modification that increases CoA acylating aldehyde dehydrogenase (ALDH) activity in catalyzing conversion of 3-hydroxypropionaldehyde (3-HPA) to 3-hydroxy propionyl-CoA (3-HP-CoA); and a genetic modification that increases 3-HP-CoA dehydratase activity in catalyzing conversion of 3-HP-CoA to acrylyl-CoA; in comparison with a microorganism of the same type that is not genetically engineered.