发明名称 |
SELECTION METHOD FOR THERAPEUTIC AGENTS |
摘要 |
The invention relates to methods for detecting off-target binding of therapeutic candidates comprising the step of measuring the level of binding of a therapeutic agent with a baculovirus (BV) particle. This assay can be used, inter alia, during antibody lead generation or optimization to increase the probability of obtaining a suitable drug. |
申请公布号 |
EP2852840(A4) |
申请公布日期 |
2016.01.13 |
申请号 |
EP20130794597 |
申请日期 |
2013.05.23 |
申请人 |
F.HOFFMANN-LA ROCHE AG |
发明人 |
KELLEY, ROBERT, F.;THEIL, FRANK-PETER;BERNSTEIN, LISA;HOTZEL, ISIDRO |
分类号 |
G01N33/53;C07K16/08;G01N33/58 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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