| 发明名称 |
NEPRILYSIN INHIBITORS |
| 摘要 |
In one aspect, the invention relates to compounds having the formula: where R1-R5 and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds. |
| 申请公布号 |
EP2964616(A1) |
申请公布日期 |
2016.01.13 |
| 申请号 |
EP20140713656 |
申请日期 |
2014.03.04 |
| 申请人 |
THERAVANCE BIOPHARMA R&D IP, LLC |
发明人 |
FENSTER, ERIK;FLEURY, MELISSA;HUGHES, ADAM D. |
| 分类号 |
C07D213/75;A61K31/197;A61K31/4015;A61K31/42;A61K31/495;A61K31/5375;C07C235/78;C07C243/38;C07C259/04;C07D205/04;C07D207/16;C07D211/62;C07D233/06;C07D239/36;C07D261/04;C07D265/30;C07D295/32;C07D307/68;C07D309/08;C07D401/04;C07D491/107 |
主分类号 |
C07D213/75 |
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