发明名称 |
INHIBITORS OF MIR-499 AND MIR-208B FOR USE IN THE TREATMENT OF PATHOLOGIC CARDIAC HYPERTROPHY, HEART FAILURE OR MYOCARDIAL INFARCTION |
摘要 |
<p>The present invention relates to the identification of two microRNAs, miR-499 and miR-208b, that repress fast skeletal muscle contractile protein genes. Expression of miR-499 and/or miR-208b can be used to repress fast fiber genes and activate slow fiber genes in the treatment of musculoskeletal disorders. Inhibition of miR-499 and/or miR-208b is proposed as a treatment for cardiac hypertrophy, myocardial infarction, and/or heart failure. Pharmaceutical compositions comprising antagonists and agonists of miR-499 and miR-208b function are also disclosed.</p> |
申请公布号 |
EP2187896(B1) |
申请公布日期 |
2016.01.13 |
申请号 |
EP20080797004 |
申请日期 |
2008.07.31 |
申请人 |
THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
OLSON, ERIC;VAN ROOIJ, EVA |
分类号 |
A61K31/7105;A61K48/00;A61P9/00;A61P9/10;C12N15/11 |
主分类号 |
A61K31/7105 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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