发明名称 |
SUBSTITUTED BICYCLIC DIHYDROPYRIMIDINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY |
摘要 |
This invention relates to substituted bicyclic dihydropyrimidinones of formula 1 and their use as inhibitors of neutrophil elastase activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of pulmonary, gastrointestinal and genitourinary diseases, inflammatory diseases of the skin and the eye and other autoimmune and allergic disorders, allograft rejection, and oncological diseases. |
申请公布号 |
EP2964617(A1) |
申请公布日期 |
2016.01.13 |
申请号 |
EP20140706627 |
申请日期 |
2014.02.26 |
申请人 |
BOEHRINGER INGELHEIM INTERNATIONAL GMBH |
发明人 |
GNAMM, CHRISTIAN;OOST, THORSTEN;PETERS, STEFAN;RUDOLF, KLAUS;HOESCH, HOLGER;RIES, UWE JÖRG |
分类号 |
C07D239/82;C07D401/04;C07D403/04;C07D403/06;C07D403/12;C07D405/04;C07D405/06;C07D405/14;C07D409/12;C07D413/12;C07D417/06;C07D471/04;C07D487/04;C07D487/10;C07D498/04 |
主分类号 |
C07D239/82 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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