| 发明名称 |
N-(3-HETEROARYLARYL)-4-ARYLARYLCARBOXAMTDES AND ANALOGS AS HEDGEHOG PATHWAY INHIBITORS AND USE THEREOF |
| 摘要 |
Disclosed are novel N-(3-heteroarylaryl)-4-arylarylcarboxamides and analogs thereof, represented by the Formula I: wherein C cyclic group, D1-D4, Q1, Q2, R5 are defined herein. Compounds having Formula (I) are hedgehog pathway inhibitors. Therefore, compounds of the invention may be used to treat clinical conditions that are responsive to the inhibition of hedgehog activity, such as cancer. |
| 申请公布号 |
EP2875005(A4) |
申请公布日期 |
2016.01.13 |
| 申请号 |
EP20130819949 |
申请日期 |
2013.07.19 |
| 申请人 |
IMPACT THERAPEUTICS, INC. |
发明人 |
CAI, SUIXIONG;TIAN, YE EDWARD;KANG, SISHUN;MENG, ZHENG;GU, CHENGYUN;YIN, FENG;CHEN, SHENGZHI;ZHANG, YANG;ZHANG, XIUYAN;FEI, HONGQIANG;WANG, DONGMEI |
| 分类号 |
C07D235/18;A61K31/4184;A61K31/437;A61K31/4439;A61K31/454;A61K31/4725;A61K31/506;A61K31/517;A61K31/519;A61K31/5377;C07D213/40;C07D401/04;C07D401/12;C07D403/10;C07D403/12;C07D405/12;C07D409/04;C07D409/12;C07D413/12;C07D471/04;C07D487/04 |
主分类号 |
C07D235/18 |
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