CRYSTALLINE FORMS OF D-GLUCITOL, 1-DEOXY-1-(METHYLAMINO)-, 1-(6-AMINO-3, 5-DIFLUOROPYRIDINE-2-YL)-8-CHLORO-6-FLUORO-1, 4-DIHYDRO-7-(3-HYDROXYAZETIDIN-1-YL)-4-OXO-3-QUINOLINECARBOXYLATE

摘要

The present disclosure relates generally to crystalline forms of anhydrous D-glucitol, 1-deoxy-1-(methylamino)-, 1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-1,4-dihydro-7-(3-hydroxyazetidin-1- yl)-4-oxo-3-quinolinecarboyxlate, compositions comprising the same, and methods of making the same. Delafloxacin is an fluoroquinolone antibiotic with the chemical structure and the chemical name 1-deoxy-1-(methylamino)-, 1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-1,4-dihydro-7-(3-hydroxyazetidin-1-yl)-4-oxo-3-quinolinecarboyxlate. Studies have indicated the existence of three anhydrous polymorphs of delafloxacin, as well as a trihydrate and methanol and ethanol solvates.