Replikin-based compounds for prevention and treatment of influenza and methods of differentiating infectivity and lethality in influenza

摘要

The present invention provides methods of differentiating the infectivity and lethality of isolates of influenza virus and provides compounds for diagnosing, preventing, and treating outbreaks of influenza virus including compounds for diagnosing, preventing, and treating across different strains of influenza virus.

主权项

1. A method of preventing or treating influenza virus in a subject comprising administering to said subject in a pharmaceutically-acceptable excipient an effective amount of at least one first isolated or chemically synthesized peptide isolated from a hemagglutinin protein of an isolate of influenza virus and at least one second isolated or chemically synthesized peptide isolated from a pB1 protein of an isolate of influenza virus, wherein said first and second isolated or chemically synthesized peptides each consist of a Replikin sequence, wherein said Replikin sequences are defined as an amino acid sequence of up to 50 amino acid residues comprising:
(1) at least one lysine residue located at a first terminus of said sequence and at least one lysine residue or at least one histidine residue located at a second terminus of said sequence; (2) a first lysine residue located six to ten residues from a second lysine residue; (3) at least one histidine residue; and (4) at least 6% lysine residues, andwherein said at least one first isolated or chemically synthesized peptide comprises at least one peptide sequence of SEQ ID NO(s): 1-6 and said at least one second isolated or chemically synthesized peptide comprises at least one peptide sequence of SEQ ID NO(s): 7-12.