Compositions and method for the diagnosis, prevention and treatment of alzheimer's disease

摘要

Disclosed herein are methods of diagnosing, preventing and treating Alzheimer's disease based on the use of an inhibitor for the binding of amyloid-β (Aβ) to FcγRIIb, and a method of screening the inhibitor. The inhibitor is selected from the group consisting of an FcγRIIb protein or a variant thereof, an FcγRIIb extracellular domain, an anti-FcγRIIb antibody, an FcγRIIb-specific peptide and an FcγRIIb-specific siRNA. The inhibitor reduces the toxic signaling and intracellular translocation of Aβ and the neurotoxicity, neuronal cell death and memory impairment mediated by Aβ by inhibiting the binding between Aβ and FcγRIIb. Thus, the inhibitor is useful in the diagnosis, prevention and treatment of Alzheimer's disease.

主权项

1. A method of treating Alzheimer's disease in a subject comprising administering to the subject an agent inhibiting interaction between amyloid-β (Aβ) and Fcγ receptor IIb (FcγRIIb), wherein the agent inhibiting interaction between Aβ and FcγRIIb is a peptide consisting of the amino acid sequence of SEQ ID NO: 19 or SEQ ID NO: 27, and wherein the peptide is administered to the subject by intracerebroventricular injection.