| 发明名称 |
Glucagon-like peptide-1 glycopeptides |
| 摘要 |
Methods and materials are provided for the production of glycosylated GLP-1 peptides that exhibit improved properties. The methods and materials of the present invention may be used for treatment of metabolic conditions, such as Syndrome X and diabetes. |
| 申请公布号 |
US9234023(B2) |
申请公布日期 |
2016.01.12 |
| 申请号 |
US201113805461 |
申请日期 |
2011.06.24 |
| 申请人 |
Biousian Biosystems, Inc. |
发明人 |
Bilsky Edward J.;Polt Robin;Senderowitz Hanoch |
| 分类号 |
A61K38/22;C07K14/575;C07K14/605;A61K47/48;A61K38/00 |
主分类号 |
A61K38/22 |
| 代理机构 |
|
代理人 |
Lazar Steven R. |
| 主权项 |
1. A GLP-1 agonist comprising a polypeptide having a C-terminal amino acid with an O-linked carbohydrate, the polypeptide sequence selected from the group consisting of: Sequence ID No. 29, Sequence ID No. 30, Sequence ID No. 31, and Sequence ID No. 32, wherein the O-linked carbohydrate is a monosaccharide selected from the group consisting of glucose; galactose; xylose; fructose; mannose; fucose; ribose; deoxyribose; arabinose; and rhamnose. |
| 地址 |
Lexington MA US |
