Chemical molecules that inhibit the slicing mechanism for treating diseases resulting from splicing anomalies

摘要

The present invention relates to a compound of one of the formulas I to XXI; a pharmaceutical composition comprising at least one such compound; and the use of at least one such compound in preparing a drug to treat, in a subject, a genetic disease resulting from at least one splicing anomaly.

主权项

1. A compound selected from the group consisting of:
N-(3-Dimethylamino-propyl)-3-(4-trifluoromethoxy-phenylamino)-benzamide; 4-(4-Methoxy-phenylamino)-3-methyl-N-(3-methyl-butyl)-benzamide; 3-Methyl-N-(3-methyl-butyl)-4-(4-trifluoromethoxy-phenylamino)-benzamide; N-(2-Dimethylamino-ethyl)-2-(4-trifluoromethoxy-phenylamino)-benzamide; N-(2-Diethylamino-ethyl)-2-(4-trifluoromethoxyphenylamino)-benzamide; N-(2-Diethylamino-propyl)-2-(4-trifluoromethoxy-phenylamino)-benzamide; (N-Diethylamino)-{1-[4-(4-Methoxy-phenylamino)-phenyl]-1H-1,2,3-triazol-4-yl}-methylamine; (N-Diethylamino)-{1-[4-(4-trifluoromethoxyphenylamino)-phenyl]-1H-1,2,3-triazol-4-yl}-methylamine; (N-Diethylamino)-{1-[4-(4-N-dimethylamino-phenylamino)-phenyl]-1H-1,2,3-triazol-4-yl}-methylamine; N-(3-Imidazol-1-yl-propyl)-2-(4-methoxy-phenylamino)-benzamide; N-(3-Imidazol-1-yl-propyl)-2-(4-trifluoromethoxy-phenylamino)-benzamide; 2-(4-Dimethylamino-phenylamino)-N-(3-imidazol-1-yl-propyl)-benzamide; N-(4-Diethylamino-1-methyl-butyl)-2-(4-dimethylaminophenylamino)-benzamide; N-(2-Dimethylamino-ethyl)-4-(4-trifluoromethoxy-phenylamino)-benzamide; N-(2-Dimethylamino-ethyl)-4-(4-dimethylamino-phenylamino)-benzamide; N-(2-Dimethylamino-ethyl)-4-(4-methoxy-phenylamino)-3-methyl-benzamide; N-(3-Diethylamino-propyl)-4-(4-methoxy-phenylamino)-3-methyl-benzamide; N-(3-Diethylamino-propyl)-3-methyl-4-(4-trifluoromethoxy-phenylamino)-benzamide; N-(3-Diethylamino-propyl)-4-(4-dimethylamino-phenylamino)-3-methyl-benzamide; N-(2-Dimethylamino-ethyl)-3-methyl-4-(4-trifluoromethoxy-phenylamino)-benzamide; 3-{1-[4-(4-Methoxy-phenylamino)-phenyl]-1H-1,2,3-triazol-4-yl}-propan-1-ol; (N-diethylamino)-{1-[3-(4-Methoxy-phenylamino)-phenyl]-1H-1,2,3-triazol-4-yl}-methylamine; [4-(5-Chloro-1H-imidazol-2-yl)-2-methyl-phenyl]-(4-methoxy-phenyl)-amine; N-(2-Diethylamino-ethyl)-4-(4-methoxy-phenylamino)-benzamide; N-(2-Dimethylamino-ethyl)-2-(4-methoxy-phenylamino)-benzamide; 4-(4-Methoxy-phenylamino)-N-(3-methyl-butyl)-benzamide; N-(3-Imidazol-1-yl-propyl)-4-(4-trifluoromethoxy-phenylamino)-benzamide; [3-(4-Diethylaminomethyl-[1,2,3]triazol-1-yl)-phenyl]-(4-dimethylamino)-phenylamine; N-(2-Diethylamino-ethyl)-2-(4-methoxy-phenylamino)-benzamide; 3-{1-[3-(4-Trifluoromethoxy-phenylamino)-phenyl]-1H-[1,2,3]triazol-4-yl}-propan-1-ol; 3-{1-[3-(4-Dimethylamino-phenylamino)-phenyl]-1H-[1,2,3]triazol-4-yl}-propan-1-ol; N-(3-Diethylamino-propyl)-2-(4-methoxy-phenylamino)-benzamide; and pharmaceutically acceptable salts thereof.