| 摘要 |
The present invention provides stereoselective processes for the preparation of compounds of formula (I) wherein P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered bicyclic heteroaryl group containing one or two nitrogen atoms as ring members, and wherein the phenyl, naphthyl and heteroaryl groups are optionally substituted; R1 is chlorodifluoromethyl or trifluoromethyl; R2 is optionally substituted aryl or optionally substituted heteroaryl; n is 0 or 1; including the process comprising (a-i) reacting a compound of formula II wherein P, R1 and R2 are as defined for the compound of formula I; with nitromethane in the presence a chiral catalyst to give a compound of formula III Wherein P, R1 and R2 are as defined for the compound of formula I; and (a-ii) reductively cyclizing the compound of formula III to give the compound of formula I. The invention also provides intermediates useful for processes for the synthesis of compounds of formula (I).; |
| 主权项 |
1. A process for the preparation of the compound of formula I wherein P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered bicyclic heteroaryl group containing one or two nitrogen atoms as ring members, and wherein the phenyl, naphthyl and heteroaryl groups are optionally substituted; R1 is chlorodifluoromethyl or trifluoromethyl; R2 is optionally substituted aryl or optionally substituted heteroaryl; n is 0 or 1; comprising (a-i) reacting a compound of formula II wherein P, R1 and R2 are as defined for the compound of formula I; with nitromethane in the presence a chiral catalyst to give a compound of formula III wherein P, R1 and R2 are as defined for the compound of formula I; and (a-ii) reductively cyclising the compound of formula III to give the compound of formula I; or (b-i) reacting a compound of formula II wherein P, R1 and R2 are as defined for the compound of formula I; with a source of cyanide in the presence of a chiral catalyst to give a compound of formula IV wherein P, R1 and R2 are as defined for the compound of formula I; and (b-ii) reductively cyclising the compound of formula IV to give the compound of formula I, wherein n is 0; or (c-i) reacting a compound of formula II wherein P, R1 and R2 are as defined for the compound of formula I; with a compound of formula XXII wherein wherein W is hydrogen or optionally substituted aryl, Y is optionally substituted aryl, and Z is optionally substituted alkyl or optionally substituted arylalkylene; in the presence a chiral catalyst to give a compound of formula XXIII wherein P, R1 and R2 are as defined for the compound of formula I, and Y, W and Z are as defined for the compound of formula XXII; (c-ii) treating the compound of formula XXIII with a suitable acid or a suitable base to release Y— C(═O)—W and give the compound of formula XXIV wherein P, R1 and R2 are as defined for the compound of formula I and Z is as defined for the compound of formula XXII; and (c-iii) decarboxylating the compound XXIV to give the compound I, wherein n is 0; or (d-i) reacting a compound of formula XXV wherein R1 and R2 are as defined for the compound of formula I; with a compound of formula XXVI wherein P is as defined for the compound of formula I; in the presence a chiral catalyst to give a compound of formula III wherein P, R1 and R2 are as defined for the compound of formula I; and (d-ii) reductively cyclising the compound of formula III to give the compound of formula I. |
