Inhibitors and methods of inhibiting bacterial and viral pathogens

摘要

Compounds, pharmaceutical compositions and methods for treating viral and bacterial infections, by administering certain thiourea compounds, specifically acylthiourea, carboximidoylthiourea and S-alkyl isothiourea derivatives and analogs, in therapeutically effective amounts are disclosed.

主权项

1. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound having the following general Formula II or a pharmaceutically acceptable salt thereof: wherein X is selected from the group consisting of oxygen and NH; Y is selected from the group consisting of: —CH2—, —C(═O)—, —C(═S)— and —C(═NH)—; A is selected from the group consisting of: N and CR5; B is selected from the group consisting of: N and CR6; R1 is selected from the group consisting of: hydrogen and ethyl; R2 is selected from the group consisting of: hydrogen and chloro; R3 is selected from the group consisting of: hydrogen, methoxy, amino and hydroxyl; R4 is selected from the group consisting of: hydrogen, chloro and amino; R5 is selected from the group consisting of hydrogen and aminomethyl; and R6 is selected from the group consisting of hydrogen, amino and aminomethyl and wherein R3 and R4 cannot both be hydrogen.