发明名称 |
Use of aptamers in therapy and/or diagnosis of autoimmune diseases |
摘要 |
The present invention is directed to an aptamer comprising or consisting of the nucleic acid sequence of SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3 and/or a nucleic acid sequence being at least 80% identical to one of SEQ ID No. 1, 2 and 3 for use in therapy and/or diagnosis of autoimmune diseases, wherein the autoimmune disease is cardiomyopathy, dilated cardiomyopathy (DCM), peripartum cardiomyopathy (PPCM), idiopathic cardiomyopathy, Chagas' cardiomyopathy, Chagas' megacolon, Chagas' megaesophagus, Chagas' neuropathy, benign prostatic hyperplasia, scleroderma, psoriasis, Raynaud syndrome, pre-eclamsia, kidney allograft rejection, myocarditis, glaucoma, hypertension, pulmonary hypertension, malignant hypertension, and/or Alzheimer's disease. |
申请公布号 |
US9234201(B2) |
申请公布日期 |
2016.01.12 |
申请号 |
US201214003675 |
申请日期 |
2012.03.02 |
申请人 |
MAX-DELBRUECK-CENTRUM FUER MOLEKULARE MEDIZIN;CHARITÉ—UNIVERSITAETSMEDIZIN BERLIN |
发明人 |
Schimke Ingolf;Haberland Annekathrin;Wallukat Gerd |
分类号 |
A61K48/00;C07H21/02;C07H21/04;C12N15/11;C12Q1/68;C12N15/115;A61M1/36;G01N33/564 |
主分类号 |
A61K48/00 |
代理机构 |
Novak Druce Connolly Bove + Quigg LLP |
代理人 |
Novak Druce Connolly Bove + Quigg LLP |
主权项 |
1. A method of treatment or diagnosis of an autoimmune
disease, wherein an individual suffering from an autoimmune disease is administered an effective amount of an aptamer comprising a nucleic acid sequence of SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3 and/or a nucleic acid sequence being at least 80% identical to one of SEQ ID No. 1, 2 and 3, wherein the autoimmune disease is cardiomyopathy, dilated cardiomyopathy (DCM), peripartum cardiomyopathy (PPCM), idiopathic cardiomyopathy, Chagas' cardiomyopathy, Chagas' megacolon, Chagas' megaesophagus, Chagas' neuropathy, benign prostatic hyperplasia, scleroderma, psoriasis, Raynaud syndrome, pre-eclamsia, kidney allograft rejection, myocarditis, glaucoma, hypertension, pulmonary hypertension, malignant hypertension, and/or Alzheimer's disease,
wherein autoantibodies specific for a G-protein coupled receptor are present in the serum of said individual suffering from said autoimmune disease,and wherein said aptamer binds specifically and with high affinity to said autoantibodies. |
地址 |
Berlin DE |