Adhesive preparation

摘要

An adhesive preparation comprising a stretchable support and an adhesive layer laminated on at least one side of the support, wherein
the stretchable support comprises a interlock woven fabric subjected to crimping processing,the adhesive layer contains 10% by mass or more of methyl salicylate with respect to the total mass of the layer,the whole adhesive preparation has moisture permeability of 1 to 350 g/m2·24 hr measured at a temperature of 40° C. and a relative humidity of 90%, andthe methyl salicylate has a plasma AUC0-24 ranging from 3.0 to 60.0 ng·hr/mL in terms of a mean±standard deviation, and salicylic acid as a metabolite of the methyl salicylate has a plasma AUC0-24 ranging from 5000 to 13000 ng·hr/mL in terms of a mean±standard deviation, when the adhesive preparation is applied to a human skin for 8 hours such that an application amount of the adhesive layer applied is 50 to 300 g/m2 and a contact area is 280 cm2.

主权项

1. An adhesive preparation comprising:
a stretchable support and an adhesive layer, wherein the adhesive layer is laminated on at least one side of the support and comprises a thermoplastic elastomer, and 10% by mass or more of methyl salicylate with respect to the total mass of the layer, wherein the whole adhesive preparation has moisture permeability of 1 to 350 g/m2·24 hr measured at a temperature of 40° C. and a relative humidity of 90%, and wherein a plasma Cmax of salicylic acid is achieved within 12 hours of administration of the adhesive preparation.