| 发明名称 | High affinity VEGF-receptor antagonists | ||
| 摘要 | A cell-based screen is reported can be used to identify specific receptor-binding compounds in a combinatorial library of peptoids (N-alkylglycine oligomers) displayed on beads. This strategy was applied to the isolation of Vascular Endothelial Growth Factor Receptor 2 (VEGFR2)-binding peptoids, which were optimized to create lead compounds with high affinity for VEGFR2. One of these peptoids was shown to be an antagonist of VEGF-VEGFR2 interaction and receptor function. | ||
| 申请公布号 | US9233162(B2) | 申请公布日期 | 2016.01.12 |
| 申请号 | US201012950425 | 申请日期 | 2010.11.19 |
| 申请人 | The Board of Regents of the University of Texas System | 发明人 | Kodadek Thomas;Udugamasooriya D. Gomika;Brekken Rolf |
| 分类号 | A61K38/08;A61P35/00;A61P35/04;C12N5/071;C40B30/04;B82Y5/00;A61K47/48;A61K45/06;A61K49/00 | 主分类号 | A61K38/08 |
| 代理机构 | Parker Highlander PLLC | 代理人 | Parker Highlander PLLC |
| 主权项 | 1. A method of inhibiting VEFG signaling comprising contacting a cell expressing a VEGFR2 with a compound having the formula: | ||
| 地址 | Austin TX US | ||