Dry powder formulations and methods for treating pulmonary diseases

摘要

The present invention is directed toward respirable dry particles for delivery of divalent metal cation salts and/or monovalent cation salts to the respiratory tract and methods for treating a subject having a respiratory disease and/or infection.

主权项

1. A respirable dry powder comprising respirable dry particles comprising magnesium lactate, one or more therapeutic agents, leucine, and optionally one or more additional excipients, wherein the respirable dry particles comprise about 20% (w/w) to about 80% (w/w) magnesium lactate, and a total amount of about 20% (w/w) to about 60% (w/w) therapeutic agents; and wherein all components of the respirable dry particles amount to 100 weight percent, wherein the respirable dry particles have a volume median geometric diameter (VMGD) of 10 microns or less, a dispersibility ratio (1/4 bar) of 2.0 or less as measured by laser diffraction (RODOS/HELOS system), and a tap density of greater than 0.4 g/cc.