| 发明名称 | Modified Cpn10 and PRR signalling | ||
| 摘要 | The present invention relates to isolated Cpn10 polypeptides possessing an increased affinity for a PRR ligand compared to Ala Cpn10 polypeptide. In a further embodiment, the present invention also relates to modified chaperonin 10 polypeptides, and to nucleic acids encoding the same and to compositions comprising such polypeptides and uses thereof. | ||
| 申请公布号 | US9234019(B2) | 申请公布日期 | 2016.01.12 |
| 申请号 | US200912934980 | 申请日期 | 2009.04.09 |
| 申请人 | CBio Limited | 发明人 | Naylor Dean Jason;Brown Richard James;Howard Christopher Bruce;De Bakker Christopher John;Ward Linda Alisson;Stok Jeanette Elizabeth;James Andrew Leigh;Lambert Daniel Scott;Ralston Kylie Jane;Van Heumen Walter Rene Antonius |
| 分类号 | A61K38/16;C07K1/00;C07K14/47;A61K38/00 | 主分类号 | A61K38/16 |
| 代理机构 | Ditthavong & Steiner, P.C. | 代理人 | Ditthavong & Steiner, P.C. |
| 主权项 | 1. An isolated Cpn10 polypeptide possessing an increased affinity for a PRR ligand compared to Ala-Cpn10 polypeptide, the isolated Cpn10 polypeptide comprising the amino acid sequence selected from the group consisting of SEQ ID NO:58, SEQ ID NO:88, SEQ ID NO:91, SEQ ID NO:94, SEQ ID NO:181, SEQ ID NO:193, SEQ ID NO:229, SEQ ID NO:256, SEQ ID NO:259, SEQ ID NO:304, SEQ ID NO:310, SEQ ID NO:328 and SEQ ID NO:349. | ||
| 地址 | Queensland AU | ||